If you are diagnosed with amebiasis, your doctor may prescribe Tindamax®, which is effective for treating the infection.
Simple dosing with high cure rates
Tindamax® dosing varies for adults and children according to the specific infection, but it is generally short in duration and very effective. For adults, the recommended treatment is one 2-gram dose a day for 3 days amebiasis, or 3-5 days for amebic liver abscess.
Figure 1 summarizes results from multiple studies on the efficacy of tinidazole in GI infections. The average cure rate in adults is 92% for intestinal amebiasis and 93% for amebic liver abscess.
Results of treatment studies for GI infections
† 8 randomized, comparative studies.1-7 Cure rates ranged from 80%-100%.
‡ 4 randomized, comparative studies.1,8-10 Cure rates ranged from 86%-93%.
§ 7 randomized, comparative studies;1,11-16 4 studies utilized at least 3 days of tinidazole. Cure rates ranged from 81%-100%.
Figure 1
Important Safety Information
WARNING: POTENTIAL RISK FOR CARCINOGENICITY
Carcinogenicity has been seen in mice and rats treated chronically with metronidazole, another nitroimidazole agent. Although such data have not been reported for tinidazole, the two drugs are structurally related and have similar biologic effects. Its use should be reserved for the conditions described in INDICATIONS AND USAGE.
Contraindications
- Prior history of hypersensitivity to tinidazole or other nitroimidazole derivatives
- First trimester of pregnancy
- Nursing mothers, unless breast-feeding is interrupted during tinidazole therapy and for 3 days following the last dose
Warnings and Precautions
- Seizures and neuropathy have been reported. Discontinue Tindamax if abnormal neurologic signs develop
- Vaginal candidiasis may develop with Tindamax and require treatment with an antifungal agent
- Use Tindamax with caution in patients with blood dyscrasias. Tindamax may produce transient leukopenia and neutropenia
Adverse Reactions
Most common adverse reactions for a single 2 g dose of tinidazole (incidence >1%) are metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, headache, dizziness and constipation. To report SUSPECTED ADVERSE REACTIONS, contact Mission Pharmacal Company at 1-800-298-1087 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
This material is intended to provide basic information. Patients should discuss all medical advice, diagnosis, and treatment with their healthcare provider.
Please see full Prescribing Information
- Bakshi JS, Ghiara JM, Nanivadekar AS. How does tinidazole compare with metronidazole? A summary report of Indian trials in amoebiasis and giardiasis. Drugs. 1978;15 Suppl 1:33-42.
- Jokipii L, Jokipii AM. Single-dose metronidazole and tinidazole as therapy for giardiasis: success rates, side effects and drug absorption and elimination. J Infect Dis. 1979 Dec;140(6):984-8.
- Kyrönseppä H, Pettersson T. Treatment of giardiasis: relative efficacy of metronidazole as compared with tinidazole. Scand J Infect Dis. 1981;13(4):311-2.
- Gazder AJ, Banerjee M. Single-dose treatment of giardiasis in children: a comparison of tinidazole and metronidazole. Curr Med Res Opin. 1977;5(2):164-8.
- Nigam P, Kapoor KK, Kumar A, Sarkari NB, Gupta AK. Clinical profile of giardiasis and comparison of its therapeutic response to metronidazole and tinidazole. J Assoc Physicians India. 1991 Aug;39(8):613-5.
- Krishnamurthy KA, Saradhambal V. Single dose therapy of giardiasis: A comparative study of tinidazole and metronidazole in pediatric patients. Indian Pediatr. 1978 Jan;15(1):51-6.
- Speelman P. Single-dose tinidazole for the treatment of giardiasis. Antimicrob Agents Chemother. 1985 Feb;27(2):227-9.
- Swami B, Lavakusulu D, Devi CS. Tinidazole and metronidazole in the treatment of intestinal amebiasis. Cur Med Res Opin. 1977;5(2):152-6.
- Singh G, Kumar S. Short course of single daily dosage treatment with tinidazole and metronidazole in intestinal amebiasis: a comparative study. Cur Med Res Opin. 1977;5(2):157-60.
- Misra NP, Gupta RC. A comparison of short course single daily dosage therapy of tinidazole with metronidazole in intestinal amoebiasis. J Int Med Res. 1977;5(6):434-7.
- Kundu SC, Sen A, Bhattacherjee TD, Dasgupta DP, Majumdar S, Moorkerjee PK, Mukerjee AB. Comparative evaluation of tinidazole and metronidazole in the treatment of amoebic liver abscess. J Ind Med Assoc. 1977 Sep 16;69(6):127-9.
- Islam N, Hasan K. Tinidazole and metronidazole in hepatic amoebiasis. Drugs. 1978;15 Suppl 1:26-9.
- Khokhani RC, Garud AD, Deodhar KP, Sureka SB, Kulkarni M, Damle VB. Comparative study of tinidazole and metronidazole in amoebic liver abscess. Curr Med Res Opin. 1977;5(2):161-3.
- Mathur SN, Itigi A, Krishnaveni, Rai V. Tinidazole and metronidazole in the treatment of amoebic liver abscess. J Int Med Res. 1977;5(6):429-33.
- Simjee AE, Gathiram V, Jackson TF, Khan BF. A comparative trial of metronidazole v. tinidazole in the treatment of amoebic liver abscess. S Afr Med J. 1985 Dec 21;68(13):923-4.
- Mendis S, Dharmasena BD, Jayatissa SK. Comparison of tinidazole with metronidazole in the treatment of hepatic amoebiasis: a controlled double blind study. Ceylon Med J. 1984 Jun;29(2):97-100.
Only Tindamax® is approved to treat both bacterial vaginosis and trichomoniasis (TV).
Clinical Insight
Oral vs vaginal cream therapy: Patient preference for oral dosing is demonstrated to be 84%. More»
Beyond BV
Tindamax® may be prescribed for other infections including:
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